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We did not observe any change in spontaneous physical activity level and we found that calorie-matched group did not lose weight to the same extent as the Melanotan-treated animals, suggesting that the drug increases energy expenditure

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Recent studies suggest that some NSAIDs directly inhibit DPP4, thus elevating endogenous GLP-1 [19]

Compared with the control group, the expression of common efflux pump genes ( acrA , acrB , tolC , and rob1 ) was increased in the NAC group (Figure 5b), suggesting that NAC promotes the enhancement of efflux pump activity